Having pummeled Cuba and Mexico, Category 4 storm projected to be the first major hurricane on record to pass through bay abutting US state's Big Bend area
Storm expected to make US landfall Sunday afternoon, battering New Orleans on 16th anniversary of Hurricane Katrina; 'Extended power loss is almost certain,' says city official
Category 1 storm with 140 kph winds, set to also reach South Carolina, Washington, Philadelphia and New York; Florida escaped after Isaias hit Caribbean islands
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