Tens of billions of dollars at stake after failure of last-minute efforts to reach settlement between companies and plaintiffs

As states, localities tussle over terms of agreement, pharmaceutical firms say they're unwilling to top initial $48 billion offer

Source says nationwide agreement could be worth tens of billions of dollars; Israeli manufacturer would contribute some $15 billion in overdose antidotes, treatment drugs

Many local governments suing pharmaceutical giant over role in opioid crisis say settlement offer doesn't hold owners accountable for over 400,000 overdose deaths

Sackler family, whose company Purdue Pharma has been blamed in opioid epidemic, gave over $60 million to universities around the world, donations now seen as blood money by some

Sacklers and their pharmaceutical firm, facing thousands of state and federal cases, are attempting to reach settlement in bankruptcy court

Men accused of conspiring and distributing cocaine and oxycodone pills laced with fentanyl that caused Jewish musician's death in September 2018

US District Court Judge Dan Polster says he has done nothing to favor those seeking money from pharmaceutical industry as its lawyers accuse him of bias against drug makers

Attorneys for owners of company at center of national opioid crisis say dealing with flow of fresh legal papers diverts resources from actually reaching a settlement

Purdue Pharma legal battle heightens debate over how much nonprofits should rely on the rich, and whether conditions should be imposed on their gifts